240mg’s, i can barely stomach 20mg, coedine makes me really sick for some reason…..

thats what i mean, theres alot then theres too much

I’d stick to 120mg max, do it less often and take an anti histamine to stop the itching.

The usual recomended total daily adult dose would be a max of 240 mg (a 60 mg dose 4 times a day).

I think an average person can take roughly upto about 400mg (give or take) of codine – with a big tollerance b4 it becomes pointless and dangerous – this is a dose that would most likely put you in hospital with all maner of possable complications if you don’t have a tollerance. Codeine is metabolized into morphine, and overdose can result in respiratory failure and cardiac arrest..

Taking more then 400mg(ish) is pointless as for an average human as taking anymore does nothing extra as your liver can only convert about 400mg codine into morphine in one go.
(I belive due to the fact that a bi-product of the metabolism process blocks the livers ability to actuly motabalise codine – so esentualy it caps at around the 400mg mark as the codine stops it’s self from working at a higher dose).

Disclaimer:- i’m not sure if it’s base or phosphate for that 400mg figure tho so reaserch more into it – i’ll get on to that part a bit later. Also I’m not a doctor but this is what I can gather from my reaserch into it … allways best to check your self too!

But I can say I’ve taken 200mg-300mg codine phosphate in one go before 2-3 times in one day, multiple days in a row, with a tollerance and had no ill effects. My doses were at least 5-6ish hours apart as it takes a while for the self metabolism blocking effects codine has on it’s self to wear off – I’m a bit sketchy on the exact details in this perticuler paragraph with regards to acurasy of dose seperation, but it semed to be fine for me – but that’s me and not you – every one reacts slightly diferantly at least – some more extreamly – so bare that in mind.

If you have no tollerance I wouldn’t go over 100ish mg codine phosphate in one go really as you’ll most likely start to feel sick at that dose (alltho you could feel sick with less then that depending on your metabolism). The min lethal dose in humans can range from about 500mg-1000mg (LD50 800mg) again depending on tollerance/weight etc. and not forgetting you can get very ill and not die at lower doses then min lethal ones! … but as I said over 400mg (depending slightly on weight/ and your specific matabolism rate) it’ll not get you “more buzzing” just make you alot sicker and a lot more itchy or worse depending how much over 400mg you go . Alltho there are some people who have tollerances and matabalisms that let them take way more then the average human and matabolise it and still be fine, you don’t want to find out you’re not one of these people as all the info I’m giving you is for an average human and there are also people with much lower threshholds (even taking close to the 400mg line I really wouldn’t recomend).

Also make sure there’s no fucking parasetamol/nurophen/asprin in the ones you’re taking if you go over the dose it sais on the box as you’ll really fuck your self up then!

The important diferances between codine base and codine phosphate (there are other types as well but phosphate is the main one availible from uk scripts) is the moleculer weight vs amount of codine (or potency). Codine base is a purer codine then the posphate vertion as it has extra bit’s to it’s chemicle structure making it heavyer then codine base. There’s less codine in codine phosphate then codine base of the same weight because of these extra bits so the dose for codine base is less then codine phosphate.

Now what I would do (unless you can find out for sure which type of codine the 400mg absolute maximum there is any point in taking mark applys to) is assume the 400mg is talking about the codine phosphate. This way if it is the codine bass that caps at 400mg, all that will happen is you’ll be taking less then 400mg of codine bass as you’ll be taking 400mg or the phosphate which is less potent. remeber to check what type of codine it is you’re taking as well.

Also don’t forget 400mg is generaly THE VERY MAXIMUM there’s any point in taking, but even with a tollerance it might not be safe … so don’t suddenly go “I’m taking 400mg” cos that’s just stupid …. if you’re ok with the dose you’re taking don’t go higher, and to be perfectly hounest, like other people have said if you can take 200mg+ you’re probably building up a fair bit of a tollerance allready (and dependancy most likely if it’s a reguler thing), so might wanna try gradualy decreasing your dose if anything (unless of corse it’s for legitimate pain relief, but if you need to take 200mg+ to stop the pain, get something stronger from your docs rather then take massive dose’s of codine) – I’ve taken codine b4 regulaly for a slipped disk at quite high doses and it’s not nice coming off them!

You can take an anti hystamine’s to help stop the itching, but certain types (like promethazine) will increase the codine to morphine motabolism rate (and also has it’s own sedative effects) so make sure you dose lower when doing them together for the first time just encase and try to find any info online about taking codine and them perticuler brand of anti hystamine. Don’t forget even one’s that don’t increase the conversion rate can still make you feel drousy. 😉

Hope this helps.
(I’ll see if I can find out for sure weather it’s bass or phosphate that the 400mg level apply to alltho you maight as well just stick to assuming it’s phosphate and less for codine bass, as it’ll be safer)

All the info I’m giving you is for an average human but I’ve also modistly worked the figures out, so as to alow slight head room and make it safer info for people reading this.

I can’t stress enough tho that you should do the reaserch your self as well cos I’ve seen people acsidently type 100mg instead of 10mg etc. quite alot in online drugs dose advice which could be well dangerous depending on what drug it is. So allways check, double check and check again all the info you find as I’ve made a few mistakes in my personal dosing and had a few scares before – hence why I now know all this shit ^^^. :laugh_at:

If I’ve missed anything out or anyone notices any inacuracies please feel free to correct me. :love:

[EDIT] And like other people have said – regula use at that high a dose will most likely cause you some inturnal psysical problems later on in life if you do it for long enough. (liver mainly I think but possably kidneys too)